Discover The Hormone-Free Estrogen Mimic To Reduce Anxiety, Sweaty Sleepless Nights And Upsetting Changes “Down There”

 66% Reduction In Anxiety Over Just 12 Weeks → 100% Stimulant-Free

CalmAgain™️ | Anxiety, Night Sweat, Sleep and Hot Flash Relief

Rated 4.8 out of 5
Based on 72 reviews

Per Bottle: 30 Easy-To-Swallow Tablets | 30 Days Supply | $1.97 Per Serving

BEST VALUE
  • Discount Save up to 25% on every order
  • free shippingFree priority shipping and delivery protection
  • Like iconRecommended for customers who love the product, no money-back guarantee, with maximum savings
Shipping Frequency
  • Save up to $39 when you shop 2 or 3 bottles
  • Free shipping on 2 or 3 bottles
  • 90-day money-back guarantee for new customers
Select Quantity
1 Bottle
  • Reduce intensity and frequency of hot flashes and night sweats within 12 weeks
  • Formulated with the same ingredient strain, dosage, and efficacy used in clinical studies
  • Jointly formulated with a Naturopathic Doctor (ND)

CalmAgain Helps Women Of All Ages Soothe The Symptoms of Low Estrogen

NO MORE HOT FLASHES

80% of American women will experience hot flashes when they enter menopause. CalmAgain’s thermoregulation formula helps to significantly reduce hot flashes, allowing you to wear your favorite outfits again and keep your cool throughout the day

No More Mood Swings

Whether it’s anxiety, depression, bouts of rage, or even sudden crying spells brought on by hormonal imbalance, CalmAgain helps support your estrogen levels with natural mood-enhancing ingredients so you can return to a happier, healthier you.

NO More Night Sweats

CalmAgain’s formula is specifically designed to help shield you from night sweat flare-ups so you can quit changing your pajamas in the middle of the night, burning through your AC bill, or wasting money on cooling aids.

Hundreds of Women Are Waving GOODBYE To Hot Flashes, Mood Swings, And Night Sweats With CalmAgain

starstar

“I would get hot flashes where my face would actually drip with sweat and would last for about 5 minutes straight. I’ve tried temperature regulating sheets, taking Evening Primrose and even acupuncture. Since I’ve been taking CalmAgain, it’s completely stopped. CalmAgain results were noticeable and lasting within 30 days. I could actually sleep through the night without kicking off the covers…no sweating! My mood has also improved.”

- Tina V.

starstar

“I’ve tried many different supplements for menopause and honestly found no relief for hot flashes and mood. I’ve tried everything out there and this seems to do the trick for the majority of symptoms. CalmAgain has helped. Way less hot flashes and definitely a better mood. I’m on my second bottle and will continue to purchase. It’s the only thing that has helped me feel like myself again.”

- Joan H.

The Ingredients In CalmAgain Are Backed By Human Clinical Trials For Fast And Effective Menopause Support

CalmAgain’s ingredients are supported by multiple human clinical trials.

And verified by these gold-standard instruments used in clinical research:

Meet The 4 Natural Ingredients That Make Feeling CalmAgain Possible

REDUCES YOUR HOT FLASHES AND ANXIETY:

Menofelis™ Siberian Rhubarb Extract

ingredients image

Our high-quality rhubarb extract (Menofelis) is flown in straight from Germany.

Menofelis™ attaches to the body’s estrogen receptors naturally and risk-free to mimic estrogen and disperse calming benefits throughout your system.

receptor

Including support for all 11 symptoms on the Menopause Rating Scale:

  • Hot flashes
  • Heart discomfort
  • Sleep problems
  • Depressive mood
  • Irritability
  • Anxiety
  • Physical and mental exhaustion
  • Sexual problems
  • Bladder problems
  • Vaginal dryness
  • Joint and muscular discomfort

It can reduce hot flashes up to 83% in just 12 weeks and reduce anxiety levels.

arrow
receptor
star

“After two weeks I realized I only had 2 or 3 hot flashes a day when I usually suffered around 6 or 8 daily. I feel less anxious, I am much calmer, and do not experience explosive or uncontrolled mood swings.”

- Maria C

Click Here To See Menofelis Clinical Trial Research

Menofelis TM 's efficacy is backed by:

CLINICAL TRIAL #1:1

**Using conventional hormone therapy only reduces the frequency of hot flashes by about 75%2


CLINICAL TRIAL #2:3

By the end, all women had on average less than 1.4 slight hot flushes per day.


CLINICAL TRIAL #3:4

Siberian rhubarb extract produced a 66% reduction in total scores on the Hamilton Anxiety Scale. A reduction in the severity of anxiety from "moderate" or "severe" to "slight" was also observed.

SUPPORTS YOUR SLEEP AND NIGHT SWEATS:

Sage (Low Thujone or Thuone-Free)

ingredients image

The phytoestrogens in sage bind to your estrogen receptors to help your body control its temperature better as estrogen levels lower in menopause.

receptor

Meaning no more changing sticky pajamas in the middle of the night, or feeling like you've wet the bed.

Sage has been clinically proven to cut night sweats down by 64% in just 8 weeks.

arrow
receptor
star

“I have absolutely seen a huge change in the amount of hot flashes and night sweats I was experiencing before taking Calm Again! Calm Again has basically eliminated those for me now. It's been amazing to be able to sleep so much better at night!”

- Vicky A.

Click Here To See Sage Clinical Trial Research

Sage's efficacy is backed by:

CLINICAL TRIAL #1:5


CLINICAL TRIAL #2:6


CLINICAL TRIAL #3:7

INCREASES YOUR LIBIDO AND MOOD:

Saffron Extract

ingredients image

Saffron can help with sexual function, libido, and depressed moods by supporting healthy serotonin and dopamine levels in the body.8

Saffron has been shown to help decrease sex-related pain in just 4 weeks, while increasing both arousal and lubrication.

It can also make a difference in low mood, such as hormonal depression, in 4 weeks.

arrow
receptor
star

“I've noticed I am calmer. I get anxious often, and it seems to be less now. Mood swings are a lot better now!”

- Karin L.

Click Here To See Saffron Clinical Trial Research

Saffron's efficacy is backed by:

CLINICAL TRIAL #1:9

***Saffron was also found to be effective in the treatment of mild to moderate depression, similar to the effects of antidepressant drug, fluoxetine.10


CLINICAL TRIAL #2:11


CLINICAL TRIAL #3:12

In a review of five total studies, saffron supplements were significantly more effective than placebos at treating symptoms of mild-to-moderate depression.

FOR HEALTHY HAIR AND OXIDATIVE STRESS:

Vitamin E (d-alpha-tocopherol)

ingredients image

Vitamin E acts as a shield against oxidative stress to support a healthy scalp and set the scene for healthy hair growth.13

When you use Vitamin E, it swoops in and fights off those harmful elements, making sure your head is the perfect environment to grow strong, beautiful hair.

ingredients image

***(CalmAgain also features Calcium and Phosphorus which are critical minerals that contribute to hair health.)

Vitamin E has even been shown to help reduce hot flashes in just 8 weeks and help balance hormones.

arrow
receptor
star

“I am unable to do hormone therapy. CalmAgain has helped tremendously - Less hot flashes. I wanted a natural product that would get my estrogen levels where they should be.

- Susan P.

Click Here To See Vitamin E Clinical Trial Research

Vitamin E's efficacy is backed by:

CLINICAL TRIAL #1:14

CalmAgain Customers Have Reported Experiencing Positive Results Within 90 Days Like:

Feel calmer and less anxious

Feel chilled throughout the day

No more major mood swings

Reduced daily hot flashes and night sweats

Better mood and more confidence

Sleeping through the night again

CalmAgain Is The Fastest Way To Prepare Yourself During Perimenopause And Get Out Of The ‘Hormonal Mess’

Calmagain intro

1 Easy Addition To Your Morning Routine Can Transform Your Life In Just 12 Weeks

SUGGESTED USE

Each bottle contains a 30-day supply (30 tablets). We recommend taking 1 tablet immediately after waking up in the morning with or without food.

Enjoy a reduction in anxiety, hot flashes, night sweats and mood swings in the next 12 weeks.

Experience the life-changing benefits of feeling CalmAgain™ with menopausal symptoms no longer bothering you again.

Additional benefits may include changing the bedsheets less often, waking up feeling rested and refreshed, no longer constantly feeling on-edge, and feeling the stirrings of your libido again!🔥

Calmagain intro
Calmagain intro

Formulated For Quick And Long-Lasting Results

Calmagain intro

Safe & Effective Ingredients

Vegan, Paleo, Keto Friendly

Non-GMO, Non-Hormonal & Stimulant Free

Based On Human Clinical Trials

Hear From 1,000s Of Women Who Have Transformed Their Lives With BB Company

average rating 4.8 out of 5
Based on 72 reviews
  • 5 Stars
    63 Reviews
  • 4 Stars
    7 Reviews
  • 3 Stars
    1 Review
  • 2 Stars
    0 Reviews
  • 1 Star
    1 Review
97% of reviewers would recommend this product to a friend
Results
Rated 4 out of 5
Improved Health
Rated 4 out of 5
Overall Satisfaction
Rated 4 out of 5
72 Reviews
Reviewed by Justine D., from New Zealand
Verified Buyer
I recommend this product
Age Range
45 - 54
Gender
Female
My Results
  • Weight Loss
  • Less Bloating
  • Better Sleep
Been Using For
More Than 2 Months
Rated 4 out of 5
Review posted

Provitalise Calm Again & Slim Gut Bundle

To be honest it is hard for me to gauge the Calm Again because I was already on provitalise which I have found really effective. I think my hot flashes and night sweats have stepped up a notch because nothing seems to be calming them at the moment. I have been on one or other of your products for over.a year now with one wee break to see how I went. On my break my sleep was so bad I was really desperate to get my supply of provitalise back, and it helped a lot. I also had an issue with bloating that has settled on your products. My absolute favourite is the Slim Gut bundle.

Loading...
Results
Rated 3 out of 5
Improved Health
Rated 4 out of 5
Overall Satisfaction
Rated 4 out of 5
Was this helpful?

BB Company

Hello Justine,

Thank you for sharing your experience with our products. We appreciate your honest feedback and are delighted to hear that you've found our products effective for managing various concerns.

We understand that menopause symptoms can be challenging, and it's great that you've been able to find relief with Provitalize. While CalmAgain may not have made a noticeable difference yet, every woman's experience is unique, and it can take time for the beneficial effects to fully unfold. Clinical studies of key ingredients show that most menopausal symptoms subside after 12-19 weeks.

While the Slim Gut Bundle has been your absolute favorite, helping to alleviate bloating and providing overall support for your well-being, I'm sorry to hear about the increase in hot flashes, I can only imagine how difficult and frustrating this must be.

Women experience these symptoms due to an imbalance in their hormone levels, particularly fluctuating estrogen levels. It might be something you can discuss with your doctor.

We know that the gut is connected to the skin, digestion, hydration, nutrient metabolism, hormonal systems, and even the brain and heart. It is truly connected to overall health. If you require more intense and powerful support for your gut, you can take 3-4 capsules of Provitalize each day. Customers have observed the best effects when they take in the morning before food. However, please consult your doctor to ensure this is suitable for you.

Should you ever have any questions or need further guidance, please don't hesitate to reach out to our support team. We're here to help you.

Wishing you continued progress, improved overall well-being, and relief from any lingering menopause symptoms.

Sincerely,
Sarah
Customer Happiness Team
The BB Company

Reviewed by Charlene K., from United States
Verified Buyer
I recommend this product
Age Range
55 - 64
Gender
Female
My Results
  • More Energy
  • Better Digestion
  • Less Bloating
  • Health Improved
  • Better Mood
Been Using For
More Than 2 Months
Rated 5 out of 5
Review posted

Lovin’ Feelin’ Back

Love this stuff! On my 3rd bottle and can tell I’m getting that loving feeling again! Feeling much calmer and less anxious than before. My sleep is even better.

Loading...
Results
Rated 5 out of 5
Improved Health
Rated 5 out of 5
Overall Satisfaction
Rated 5 out of 5
Was this helpful?
Reviewed by Katie C., from United States
Verified Buyer
I recommend this product
Age Range
45 - 54
Gender
Female
My Results
  • Less Cravings
  • Reduced Hot Flashes
  • Better Mood
  • Blood Sugar In Control
  • Improved Immunity
Been Using For
More Than 2 Months
Rated 5 out of 5
Review posted

Less hot flashes

It’s helping with my hot flashes 😊

Loading...
Results
Rated 5 out of 5
Improved Health
Rated 5 out of 5
Overall Satisfaction
Rated 5 out of 5
Was this helpful?
Reviewed by Jennifer Z., from United States
Verified Buyer
I recommend this product
Age Range
45 - 54
Gender
Female
My Results
  • Better Mood
  • Better Sleep
Been Using For
1 To 2 Months
Rated 5 out of 5
Review posted

Awesome ~ something finally works!

Yes!!! Relief!!!

Loading...
Results
Rated 5 out of 5
Improved Health
Rated 5 out of 5
Overall Satisfaction
Rated 5 out of 5
Was this helpful?
Reviewed by Nijole G., from United Kingdom
Verified Buyer
I recommend this product
Age Range
55 - 64
Gender
Female
My Results
  • More Energy
  • Weight Loss
  • Better Mood
  • Reduced Hot Flashes
  • Improved Skin
Been Using For
2 to 4 Weeks
Rated 5 out of 5
Review posted

It's perfect product for me..recommended for my friends

I sleeping more better ,not flashing...really feeling more better

Loading...
Results
Rated 5 out of 5
Improved Health
Rated 5 out of 5
Overall Satisfaction
Rated 5 out of 5
Was this helpful?

Frequently Asked Questions

When can I expect results from CalmAgain?

Clinical studies of key ingredients show that most menopausal symptoms subside after 12-19 weeks.

Does CalmAgain have any side effects?

CalmAgain is not known to have any major side effects.

CalmAgain is made using high-quality, natural ingredients and has been tested safe for consumption. It was formulated to be stimulant-free, which makes it ideal for long-term consumption.

Because of its high potency, some customers may occasionally experience gastrointestinal discomfort or hypersensitivity reactions at the start. This is normal and usually goes away after a few days as your body adjusts.

But if you experience adverse effects, please stop consumption and consult a doctor. If you are on medication or suffer from health conditions, we recommend informing your doctor of your interest in consuming our supplements.

In general, you should follow the recommended dosage of 1 tablet a day. Many customers following this dosage have feedbacked experiencing more sustained effects like fewer hot flashes, night sweats, and mood swings, especially when taken in the long term.

Does CalmAgain contain gluten, soy, peanuts, dairy, shellfish, or any other allergens?

No, CalmAgain does not contain any of these mentioned ingredients or allergens. Because of that, it supports most diets like vegan, keto, paleo, and kosher.

What does Thujone Free Preparation mean?

Sage is naturally rich in thujone, which is toxic to the liver and kidneys. A thujone-free or low thujone preparation would ensure daily intake of thujone would remain below toxicity level.

What if I’m already on HRT?

Many women hesitate to start HRT due to the potential health risks and complications. Others have also mentioned that HRT doesn’t effectively help relieve menopausal symptoms.

If you’re currently already on HRT, it should be safe to consume CalmAgain even when you’re on HRT, as CalmAgain doesn’t affect estrogen levels or other hormones. However, it’s advisable to consult your doctor first before you start taking CalmAgain or if you wish to stop HRT.

Is this a one-time purchase?

Yes, rest assured that all orders on this page are one-time purchases only.

This means that you won’t be charged again in the subsequent months. There will not be any automatic recurring billing or hidden charges.

Once you’ve selected your bottles, you’ll be brought to the checkout page where you can choose to pay by credit card or Paypal.

If you select the PayPal option, you will be brought to the PayPal payment page.

Do you ship worldwide? What are the shipping charges?

Yes, we ship CalmAgain worldwide.

For orders outside the US, the shipping cost depends on the weight of your order, and the updated shipping fee will be shown at checkout.

For orders in the US, we offer free shipping for orders of 2 bottles or more.

What currency are the prices in?

All prices shown are in United States Dollars (USD), but you can purchase outside the US as we ship worldwide.

If you're using non-US currencies, the conversion will be done by your bank or payment provider and they will be reflected in your currency.

When can I expect my shipment of CalmAgain?

Below are the estimated delivery timings.

Expedited Shipping: 2 to 7 business days for orders within the US
Free Regular Shipping: 5 to 18 business days for orders within the US

Upon completion of your order, you’ll receive an email confirmation from us and an estimated delivery time. We’ll inform you if there’s any change to your shipment delivery date.

Can CalmAgain be purchased elsewhere?

We advise customers to avoid purchasing from non-approved vendors. Many counterfeit products are currently been sold online. To ensure you’re getting the genuine product, only purchase CalmAgain directly from our website.

To keep the formula fresh, and as potent as possible, we want to avoid storing it in a warehouse or a store shelf. Instead, we ship your order directly after bottling to your doorstep as fast as possible.

How does the guarantee work?

We’re so sure of the effectiveness of CalmAgain that each order comes with a 90-day money-back guarantee. Try it out for three months and the bottle to see if it works for you.

If you aren’t 100% satisfied with your results, just drop us a message and you’ll be refunded based on our terms and conditions.

How to take CalmAgain? What is the dosage?

For best results, take 1 tablet in the morning daily before breakfast with a glass of water.

What form does CalmAgain come in?

CalmAgain comes in tablet form. Each bottle contains a 30-day supply (30 Tablets).

Do I need to refrigerate CalmAgain?

No refrigeration is needed. Our product is shelf-stable and can last up to 2 years upon delivery.

Kindly store in a cool, dry place to preserve maximum potency.

Where is CalmAgain manufactured?

CalmAgain is manufactured in a GMP-certified, FDA-registered factory located in the USA.

What are the exact ingredients in CalmAgain?

The main ingredients of CalmAgain are Menofelis™ Siberian Rhubarb Extract, Saffron Extract, Sage Extract (low Thujone / Thuone-free preparation), Vitamin E (d-alpha-tocopherol).

For more information on the product, kindly refer to the product label or the ingredients listed above.

Disclaimer

These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure or prevent any medical conditions.

The testimonials presented apply only to the individuals depicted, cannot be guaranteed, and should not be considered typical.

Every testimonial on this website is from a real customer who used the product, and/or nutrition advice listed on the website.

No one was paid for a testimonial or endorsement. Results were self-reported by the customer. You should assume that any results shown in testimonials, advertisements, stories, blog posts, articles, forums, or anywhere else on this site or our associated websites are not typical. Results may vary from person to person.

References
  1. Chang, J. L., Montalto, M. B., Heger, P. W., Thiemann, E., Rettenberger, R., & Wacker, J. (2016). Rheum rhaponticum Extract (ERr 731): Postmarketing Data on Safety Surveillance and Consumer Complaints. Integrative medicine (Encinitas, Calif.), 15(3), 34–39.
  2. Kaszkin-Bettag, M., Ventskovskiy, B. M., Solskyy, S., Beck, S., Hasper, I., Kravchenko, A., Rettenberger, R., Richardson, A., & Heger, P. W. (2009). Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms. Alternative therapies in health and medicine, 15(1), 24–34.
  3. Shah, J., Chandanani, S., Reddy, J., Kirubamani, H., Boruah, A. M., Jain, A., Mane, S., Biniwale, P., Mathur, P., Ridhorkar, A., Natarajan, S., & Tiwari, B. (2021). Evaluation of the Efficacy and Safety of Rheum rhaponticum Root Extract (ERr 731) for Menopausal Symptoms in Perimenopausal Indian Women: An Interim Analysis. Journal of mid-life health, 12(2), 108–115. https://doi.org/10.4103/jmh.jmh_86_21
  4. Heger, M., Ventskovskiy, B. M., Borzenko, I., Kneis, K. C., Rettenberger, R., Kaszkin-Bettag, M., & Heger, P. W. (2006). Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause (New Y ork, N.Y .), 13(5), 744–759. https://doi.org/10.1097/01.gme.0000240632.08182.e4
  5. Kaszkin-Bettag, M., Beck, S., Richardson, A., Heger, P. W., & Beer, A. M. (2008). Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study. Alternative therapies in health and medicine, 14(6), 32–38.
  6. Hasper, I., Ventskovskiy, B. M., Rettenberger, R., Heger, P. W., Riley, D. S., & Kaszkin-Bettag, M. (2009). Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause (New York, N.Y.), 16(1), 117–131. https://doi.org/10.1097/GME.0b013e3181806446
  7. Kashani, L., Esalatmanesh, S., Eftekhari, F., Salimi, S., Foroughifar, T., Etesam, F., Safiaghdam, H., Moazen-Zadeh, E., & Akhondzadeh, S. (2018). Efficacy of Crocus sativus (saffron) in treatment of major depressive disorder associated with post- menopausal hot flashes: a double-blind, randomized, placebo-controlled trial. Archives of gynecology and obstetrics, 297(3), 717– 724. https://doi.org/10.1007/s00404-018-4655-2
  8. Lopresti, A. L., & Smith, S. J. (2021). The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study. Journal of menopausal medicine, 27(2), 66–78. https://doi.org/10.6118/jmm.21002
  9. Ziaei, S., Kazemnejad, A., & Zareai, M. (2007). The effect of vitamin E on hot flashes in menopausal women. Gynecologic and obstetric investigation, 64(4), 204–207. https://doi.org/10.1159/000106491
  10. Ataei-Almanghadim, K., Farshbaf-Khalili, A., Ostadrahimi, A. R., Shaseb, E., & Mirghafourvand, M. (2020). The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: A triple blind randomised controlled trial. Complementary therapies in medicine, 48, 102267. https://doi.org/10.1016/j.ctim.2019.102267
  11. Yousefi-Nodeh, H., Farshbaf-Khalili, A., Sadeghzadeh Oskouei, B., Jafarilar-Aghdam, N., Kazemi-Zanjani, N., & Pourzeinali, S. (2022). Curcumin and vitamin E improve hot flashes, lipid profile, and fasting blood glucose without any detrimental effect on the liver and renal function in postmenopausal women: A triple-blind placebo-controlled clinical trial. Health care for women international, 1– 23. Advance online publication. https://doi.org/10.1080/07399332.2022.2117815
  12. Bommer, S., Klein, P., & Suter, A. (2011). First time proof of sage's tolerability and efficacy in menopausal women with hot flushes. Advances in therapy, 28(6), 490–500. https://doi.org/10.1007/s12325-011-0027-z
  13. Zeidabadi, A., Yazdanpanahi, Z., Dabbaghmanesh, M. H., Sasani, M. R., Emamghoreishi, M., & Akbarzadeh, M. (2020). The effect of Salvia officinalis extract on symptoms of flushing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women. Journal of family medicine and primary care, 9(2), 1086–1092. https://doi.org/10.4103/jfmpc.jfmpc_913_19
  14. Dadfar, F., & Bamdad, K. (2019). The effect of Saliva officinalis extract on the menopausal symptoms in postmenopausal women: An RCT. International journal of reproductive biomedicine, 17(4), 287–292. https://doi.org/10.18502/ijrm.v17i4.4555
  15. Lachenmeier, D. W., & Uebelacker, M. (2010). Risk assessment of thujone in foods and medicines containing sage and wormwood--evidence for a need of regulatory changes?. Regulatory toxicology and pharmacology : RTP, 58(3), 437–443. https://doi.org/10.1016/j.yrtph.2010.08.012
  16. https://www.avogel.co.uk/herbal-remedies/sage-herb-menosan/
  17. https://www.ema.europa.eu/en/documents/scientific-guideline/public-statement-use-herbal-medicinal-products-containing-thujone- revision-1_en.pdf
  18. Coombs, N., Taylor, R., Wilcken, N., Fiorica, J., & Boyages, J. (2005). Hormone replacement therapy and breast cancer risk in california. The Breast Journal, 11(6), 410-415. https://doi.org/10.1111/j.1075-122x.2005.00132.x
  19. Chen, J., Guo, Q., Pei, Y., Ren, Q., Chi, L., Hu, R., … & Tan, Y. (2020). Effect of a short-term vitamin e supplementation on oxidative stress in infertile pcos women under ovulation induction: a retrospective cohort study. BMC Women S Health, 20(1). https://doi.org/10.1186/s12905-020-00930-w
  20. Sadeghi, A., Ghahari, L., & Yousefpour, M. (2019). Vitamin e supplementation reduces oxidative stress in the male wistar rats’ brain against polyvinyl chloride products. Annals of Military and Health Sciences Research, 17(2). https://doi.org/10.5812/amh.92768
  21. Liudvytska, O. and Kolodziejczyk-Czepas, J. (2022). A review on rhubarb-derived substances as modulators of cardiovascular risk factors—a special emphasis on anti-obesity action. Nutrients, 14(10), 2053. https://doi.org/10.3390/nu14102053
  22. Zhang, Z., Li, M., Liu, D., Chen, H., Chen, D., Tan, N., … & Zhao, Y. (2018). Rhubarb protect against tubulointerstitial fibrosis by inhibiting tgf-β/smad pathway and improving abnormal metabolome in chronic kidney disease. Frontiers in Pharmacology, 9. https://doi.org/10.3389/fphar.2018.01029
  23. Ettehadi, H., Mojabi, S., Ranjbaran, M., Shams, J., Sahraei, H., Hedayati, M., … & Asefi, F. (2013). Aqueous extract of saffron (<i>crocus sativus</i>) increases brain dopamine and glutamate concentrations in rats. Journal of Behavioral and Brain Science, 03(03), 315-319. https://doi.org/10.4236/jbbs.2013.33031
  24. Oliveira, C., Pourtau, L., Vancassel, S., Pouchieu, C., Capuron, L., Gaudout, D., … & Castanon, N. (2021). Saffron extract-induced improvement of depressive-like behavior in mice is associated with modulation of monoaminergic neurotransmission. Nutrients, 13(3), 904. https://doi.org/10.3390/nu13030904
  25. Pachikian, B., Copine, S., Suchareau, M., & Deldicque, L. (2021). Effects of saffron extract on sleep quality: a randomized double-blind controlled clinical trial. Nutrients, 13(5), 1473. https://doi.org/10.3390/nu13051473
  26. Kennedy, D., Dodd, F., Robertson, B., Okello, E., Reay, J., Scholey, A., … & Haskell, C. (2010). Monoterpenoid extract of sage (salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults. Journal of Psychopharmacology, 25(8), 1088-1100. https://doi.org/10.1177/0269881110385594
  27. Lima, C., Valentão, P., Andrade, P., Seabra, R., Fernandes-Ferreira, M., & Pereira-Wilson, C. (2007). Water and methanolic extracts of salvia officinalis protect hepg2 cells from t-bhp induced oxidative damage. Chemico-Biological Interactions, 167(2), 107-115. https://doi.org/10.1016/j.cbi.2007.01.020
  28. Pinkerton, J., Aguirre, F., Blake, J., Cosman, F., Hodis, H., Hoffstetter, S., … & Utian, W. (2017). The 2017 hormone therapy position statement of the north american menopause society. Menopause the Journal of the North American Menopause Society, 24(7), 728-753. https://doi.org/10.1097/gme.0000000000000921
  29. https://www.metagenicsinstitute.com/wp-content/uploads/2018/01/MET2390-Estrovera-Science-Review_MI.pdf
  30. Mazidi M, Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, Mokhber N, Ghayour-Mobarhan M, Ferns GA. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J Complement Integr Med. 2016 Jun 1;13(2):195-9. doi: 10.1515/jcim-2015-0043. PMID: 27101556.
  31. Kashani L, Esalatmanesh S, Eftekhari F, Salimi S, Foroughifar T, Etesam F, Safiaghdam H, Moazen-Zadeh E, Akhondzadeh S. Efficacy of Crocus sativus (saffron) in treatment of major depressive disorder associated with post-menopausal hot flashes: a double-blind, randomized, placebo-controlled trial. Arch Gynecol Obstet. 2018 Mar;297(3):717-724. doi: 10.1007/s00404-018-4655-2. Epub 2018 Jan 13. PMID: 29332222.
  32. Bommer, S., Klein, P. & Suter, A. First time proof of sage’s tolerability and efficacy in menopausal women with hot flushes. Adv Therapy 28, 490–500 (2011). https://doi.org/10.1007/s12325-011-0027-z
  33. Wightman EL, Jackson PA, Spittlehouse B, Heffernan T, Guillemet D, Kennedy DO. The Acute and Chronic Cognitive Effects of a Sage Extract: A Randomized, Placebo Controlled Study in Healthy Humans. Nutrients. 2021 Jan 14;13(1):218. doi: 10.3390/nu13010218. PMID: 33466627; PMCID: PMC7828691.
  34. Scholey, A.B., Tildesley, N.T.J., Ballard, C.G. et al. An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology 198, 127–139 (2008). https://doi.org/10.1007/s00213-008-1101-3
  35. Feduniw S, Korczyńska L, Górski K, Zgliczyńska M, Bączkowska M, Byrczak M, Kociuba J, Ali M, Ciebiera M. The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review. Nutrients. 2022 Dec 29;15(1):160. doi: 10.3390/nu15010160. PMID: 36615817; PMCID: PMC9824658.
  36. Farshbaf-Khalili A, Ostadrahimi A, Mirghafourvand M, Ataei-Almanghadim K, Dousti S, Iranshahi AM. Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized Controlled Trial. J Nutr Metab. 2022 Jun 9;2022:6339715. doi: 10.1155/2022/6339715. PMID: 35719707; PMCID: PMC9203212.