A recently published medical case report claims a patient developed acute liver failure after taking Provitalize, a natural menopause supplement. While such a report may raise understandable concern, the purpose of this article is to provide factual context, clarify the safety profile of Provitalize’s ingredients, and outline our regulatory position in response to this report.
The article presents a single case of liver injury and suggests a potential link to Provitalize. However:
Here’s a breakdown of the supplement’s formula (per 2-capsule serving):
Ingredient | Amount | Known Safety Profile |
---|---|---|
Proprietary Synbiotic Blend | 400 mg | L. gasseri, B. breve, B. lactis with FOS prebiotics—Prebiotics are classified as GRAS (Generally Recognized As Safe) by the FDA while the probiotic strains have passed genomic safety evaluation. |
Turmeric Root Extract | 350 mg | The World Health Organisation (WHO) recommends up to 1.5–3 g/day while clinical studies support up to 8 g/day. |
Moringa Leaf (7:1 Extract) | 350 mg | No adverse effects in human trials. |
Curry Leaf (Helichrysum) | 150 mg | No evidence of liver toxicity in clinical literature. |
Sunflower-Derived Lecithin | 50 mg | Common food additive found in many products such as chocolate bars, candies, pastries, and vegan products. Classified as GRAS by the FDA. |
Black Pepper Fruit Extract (BioPerine®) | 3 mg | Patented ingredient and classified as GRAS by the FDA. |
Turmeric is a bright yellow spice commonly used in curry dishes, and its active ingredient, curcumin, is known for its anti-inflammatory and antioxidant properties. Many people consume foods containing turmeric daily or take turmeric supplements to help with joint pain, arthritis, or general inflammation.
The report speculates turmeric (Curcuma longa) might be responsible for the adverse outcome. Here's what research tells us about turmeric's safety:
The toxicity studies cited in the report are based on animal models, which cannot be extrapolated to humans.
Moringa oleifera has been studied in multiple human clinical trials with no adverse effects, and has a robust history of studies and safe use in both traditional medicine and modern supplements.
Curry leaf (Helichrysum italicum) has no established association with liver injury and is commonly used in herbal formulations.
The probiotic strains in Provitalize—Lactobacillus gasseri, Bifidobacterium breve, and B. animalis subsp. lactis—are:
We maintain rigorous safety oversight at every stage of product development and post-market activity:
If a serious adverse event were ever confirmed, it would be immediately reported to the FDA under current regulatory obligations.
Provitalize has been used by millions of customers worldwide, many of whom share their feedback publicly. On Trustpilot, BBCo has earned a 4.5+ star average rating across hundreds of verified reviews.
💬 "I feel more energized, my hot flashes are gone, and I haven’t had any side effects."
💬 "It really helped with my gut health and bloating. I love this product!"
Importantly, there is no pattern of serious adverse events, such as liver-related complaints, among verified reviews—further supporting the product’s real-world safety record.
You might wonder how to interpret this case report on PubMed. Let's explore what this means in context.
PubMed is a respected scientific database managed by the U.S. National Library of Medicine. As the world's leading biomedical literature repository, it hosts millions of peer-reviewed scientific articles from prestigious journals worldwide.
While PubMed maintains high standards for indexed journals, individual articles can vary in their level of evidence:
Some are large clinical trials with extensive data
Others are preliminary findings or individual case observations
Each type of study serves different scientific purposes
The article discussing Provitalize is a case report - an important type of medical publication that documents individual clinical observations. While valuable for identifying potential areas for further research, case reports have specific limitations:
In this particular case report, the authors note a possible connection with turmeric, while acknowledging:
Scientific understanding develops through multiple studies and various types of evidence. While this case report contributes to the scientific discussion, it represents just one piece of a larger picture.
Good science requires both preliminary observations and comprehensive research to establish reliable conclusions.
This is why regulatory bodies consider multiple sources of evidence when evaluating product safety, including clinical trials, population studies, and post-market surveillance data.
The case report offers a hypothetical association between Provitalize and liver injury, without presenting definitive causal evidence. Our position is supported by:
As of today, Provitalize remains a safe supplement when used as directed. We stand by the formulation’s integrity, scientific grounding, and regulatory compliance.
If you or someone you know experiences symptoms while taking any supplement:
We treat every concern with seriousness and are committed to ensuring the health and trust of our customers.
If you have further questions, reach out to our Customer Service Team at contact@thebbco.com.
A single case report has suggested a potential link between Provitalize and liver failure; however, this claim lacks scientific rigor and definitive causal evidence. The report relies on extrapolations that fail to establish a clear connection to the observed symptoms. Importantly, our company has received no liver-related incident reports, despite maintaining rigorous post-market surveillance. Furthermore, millions of customers worldwide use the product safely, with no pattern of adverse events in our extensive user base. This substantial real-world evidence strongly contradicts the isolated case report's speculative claims..
All ingredients in Provitalize have strong safety profiles:
Provitalize follows strict quality control measures:
While PubMed is a respected scientific database, individual publications like case reports have limitations:
• Case reports document single incidents and observations
• They serve as starting points for investigation rather than definitive evidence
• Multiple sources of evidence, including clinical trials and population studies, are needed to establish safety
• Regulatory bodies consider comprehensive data when evaluating supplement safety
Written by: The BBCo Team
Last Updated: 29 Apr 2025